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Possible relationship between mitochondrial DNA polymorphisms and lithium response in bipolar disorder

Shinsuke Washizuka , Akifumi Ikeda , Nobumasa Kato , Tadafumi Kato
DOI: http://dx.doi.org/10.1017/S1461145703003778 421-424 First published online: 1 December 2003

Abstract

Although many investigators have been searching for genetic markers to predict lithium response in bipolar disorders, no genetic predictor has been established yet. We previously reported the association of mitochondrial DNA (mtDNA) 5178 and 10398 polymorphisms with bipolar disorder. The objective of this study is to clarify whether these mtDNA polymorphisms can predict response to maintenance lithium treatment in bipolar patients. We examined these polymorphisms and some clinical variables in 54 bipolar patients. A logistic regression analysis was performed and revealed that patients carrying the 10398A polymorphism showed a significantly better response to lithium (p=0.03). Some clinical variables such as sex, age at onset, and rapid cycling also showed a significant association with lithium response in univariate analysis (χ2 test, p<0.05). Our findings suggest that the mtDNA 10398 polymorphism might be related to maintenance lithium treatment response.

Key words
  • Bipolar disorder
  • lithium response
  • mitochondrial DNA
  • pharmacogenetics
  • treatment